참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | N,N-Diethyl-2-propanamine | HCID 521913 | — |
| 반응물 | Pyrazole-1-carboxamidine monohydrochloride | HCID 2734672 | — |
| 반응물 | N-(5-aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide | HCID 57678964 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178512747 | HCID 178512747 | — |
반응 단계
N-(5-Aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide, 1H-pyrazol-1-carboxamidine hydrochloride and diethyl isopropylamine are dissolved in DMF, and the reaction mixture is heated to 100° C., then cooled and diluted by addition of of water. The aqueous mixture is extracted with EtOAc, and the combined organic layers are dried over MgSO4, filtered, and concentrated under reduced pressure to give N-(5-Guanidinomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide. 5-Guanidinomethyl-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid phenylamide may be similarly prepared.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07531577B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_05 |
|---|
| ORD ID | ord-d612157112d348e8bccc63f47f406d12 |
|---|
| 출처 메모 | uspto-grants-2009_05 |
|---|
