反应详情

温度

150 °C

N-(5-Aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide and 2-methylsulfanyl-4,5-dihydro-1H-imidazole hydroiodide were added to methylene chloride and the reaction mixture was heated to reflux until all of the solvent evaporates. The reaction mixture is heated to 150° C. and then cooled. The resulting mixture is basified by dropwise addition of aqueous NaOH solution, and then purified by preparative liquid chromatography to give N-{5-[(4,5-Dihydro-1H-imidazol-2-ylamino)-methyl]-5,6,7,8-tetrahydro-naphthalen-2-yl}-benzenesulfonamide. 5-[(4,5-Dihydro-1H-imidazol-2-ylamino)-methyl]-5,6,7,8-tetrahydro-napthalene-2-sulfonic acid phenylamide may be similarly prepared.

1. temperaturethe reaction mixture was heated
2. temperatureto reflux until all of the solvent
3. customevaporates
4. temperaturecooled
5. additionThe resulting mixture is basified by dropwise addition of aqueous NaOH solution
6. custompurified by preparative liquid chromatography