Water → Gatifloxacin

Participants

Reaction Conditions

Reaction Steps

Thirty five grams of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid and 24.9 g (2.1 eq) of 2-methyl piperazine were suspended in DMSO (700 mL) under nitrogen atmosphere. The mixture was heated to 55° C. during 24 hours. Subsequently, water (70 mL) was added, the reaction mixture was cooled to 2° C. and left at this temperature for 5 hours. The solution was filtered, washed with acetonitrile and dried under vacuum to obtain 30.3 g after assay (68% yield) of gatifloxacin.

Provenance & Evidence