反应详情

80 g (322 mmol) of an (E/Z) mixture of 4-[2-(pyridin-3-yl)-vinyl-2H-isoquinolin-1-one in 3100 ml of methanol/THF 1:1 are hydrogenated in the presence of 15.2 g of Pd/C (10%). Filtration and concentration by evaporation yield the crude product. Recrystallisation by dissolving in 650 ml of boiling ethanol, hot filtration, cooling and addition of 1 l of diethylether and 0.2 l of hexane yield colourless 4-[2-(pyridin-3-yl)-ethyl]-2H-isochinolin-1-one; m.p.187-188° C.

1. filtrationFiltration and concentration
2. customby evaporation
3. customyield the crude product
4. customRecrystallisation
5. dissolutionby dissolving in 650 ml of boiling ethanol
6. filtrationhot filtration
7. temperaturecooling
8. additionaddition of 1 l of diethylether and 0.2 l of hexane