HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-5-nitrobenzotrifluoride → 3-Chloro-5-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-5-nitrobenzotrifluoride | HCID 50255 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Chloro-5-(trifluoromethyl)aniline | HCID 3017933 | — |
Reaction Steps
92 g (0.408 mol) of 5-chloro-3-trifluoromethyl-nitrobenzene in 1 l of methanol are hydrogenated in the presence of 10.17 g of Raney nickel. The reaction mixture is filtered through Celite/activated carbon and the residue washed with methanol. Concentration of the filtrate by evaporation yields the oily 5-amino-3-chloro-benzotrifluoride; 1H-NMR (DMSO-d6) δ6.80 (m, 3H), 5.92 (s, H2N).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06706731B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-990f9d25dd51402ba6bc222c113bad97 |
| Source note | uspto-grants-2004_03 |