Lithium hydroxide, monohydrate → 1-(Quinolin-4-yl)-1H-indole-3-carboxylic acid

Participants

Reaction Steps

0.37 g (8.84 mmol) of lithium hydroxide monohydrate and 45 cm3 of water are added at 25° C. to 0.89 g (2.95 mmol) of 3-methoxycarbonyl-1-(quinol-4-yl)-1H-indole dissolved in 45 cm3 of tetrahydrofuran. After stirring at reflux for 17 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) to give a residue which is taken up in 30 cm3 of water and then triturated with 8.8 cm3 of N hydrochloric acid. After filtering off and drying the solid residue under reduced pressure (2.7 kPa) at 40° C., 1 g of 3-carboxy-1-(quinol-4-yl)-1H-indole is obtained in the form of a yellow solid. Mass spectrum (EI): m/e 288 (M+·), m/e 243.

Provenance & Evidence