HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 3-Bromo-4-ethylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2-Bromo-1-ethyl-4-nitrobenzene | HCID 22345594 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Bromo-4-ethylaniline | HCID 22345617 | — |
Reaction Steps
Hydrogenation of 4.45 g (19 mmol) of 3-bromo-4-ethyl-nitrobenzene (for preparation see Macromolecules 1995, 28, 5618) in 100 ml of ethanol in the presence of 1 g of Raney nickel, followed by filtration, concentration by evaporation and chromatography (SiO2; methylenechloride), yields 3-bromo-4-ethyl-aniline; 1H NMR (CDCl3) δ6.94 (d, 1H), 6.82 (s, 1H), 6.50 (d, 1H), 3.50 (s, H2N), 2.57 (q, 2H), 1.10 (t, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06706731B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-84530c68356c47fe9e4fe9749e53d702 |
| Source note | uspto-grants-2004_03 |