Thionyl Chloride → HCID 86596405, compound

Participants

Reaction Steps

15 cm3 of thionyl chloride are added at 22° C. under an argon atmosphere to 0.95 g (2.70 mmol) of 3-carboxy-5-methyl-1-(quinol-2-yl)-1H-indole. After stirring at reflux for 3.5 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa), successively triturated twice with 10 cm3 of dimethoxyethane and then concentrated to dryness under reduced pressure (2.7 kPa) to give 1 g of 3-chlorocarbonyl-5-methyl-1-(quinol-2-yl)-1H-indole hydrochloride in the form of a yellow solid which is used directly in the following step.

Provenance & Evidence