反应详情

温度

22 °C

0.365 g (15.9 mmol) of sodium is added at 22° C. under an argon atmosphere to 45 cm3 of methanol. After complete dissolution, 1.4 g (15 mmol) of guanidine hydrochloride are added. After stirring at 22° C. for 2 hours, the reaction mixture is filtered under an argon atmosphere. The filtrate is concentrated to dryness under reduced pressure (2.7 kPa) to give a residue which is dissolved in 25 cm3 of 1,2-dimethoxyethane. 1 g of 3-chlorocarbonyl-5-methyl-1-(quinol-4-yl)-1H-indole, suspended in 20 cm3 of 1,2-dimethoxyethane, is subsequently added at 22° C. under an argon atmosphere. After stirring at 22° C. for 19 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) to give a residue which is triturated in 20 cm3 of water. After stirring at 22° C. for 1 hour, the suspension is filtered and dried to give a beige-coloured powder which is purified by flash chromatography [eluent: cyclohexane/ethyl acetate (7/3 by volume) and then dichloromethane/methanol/20% aqueous ammonia (18/3/0.5 by volume)]. After concentrating the fractions under reduced pressure (2.7 kPa), 1.1 g of a beige-coloured solid are obtained, which solid is triturated in 10 cm3 of N hydrochloric acid for 1 hour. After filtering off, the residue is recrystallised under hot conditions from 180 cm3 of methanol to give 0.66 g of 3-guanidinocarbonyl-5-methyl-1-(quinol-4-yl)-1H-indole hydrochloride in the form of pale yellow crystals melting at 268° C. (Analysis C20H17N5O.HCl; % calculated C, 63.24, H: 4.78, Cl: 9.33, N: 18.44, O: 4.21, % found C: 63.26, H: 4.72, Cl: 9.47, N: 18.57).

1. additionare added
2. filtrationthe reaction mixture is filtered under an argon atmosphere
3. concentrationThe filtrate is concentrated to dryness under reduced pressure (2.7 kPa)
4. customto give a residue which
5. additionis subsequently added at 22° C. under an argon atmosphere
6. stirringAfter stirring at 22° C. for 19 hours
7. concentrationthe reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa)
8. customto give a residue which
9. customis triturated in 20 cm3 of water
10. stirringAfter stirring at 22° C. for 1 hour
11. filtrationthe suspension is filtered
12. customdried
13. customto give a beige-coloured powder which
14. customis purified by flash chromatography [eluent
15. concentrationAfter concentrating the fractions under reduced pressure (2.7 kPa), 1.1 g of a beige-coloured solid
16. customare obtained
17. customwhich solid is triturated in 10 cm3 of N hydrochloric acid for 1 hour
18. filtrationAfter filtering off
19. customthe residue is recrystallised under hot conditions from 180 cm3 of methanol