Thionyl Chloride → HCID 86596408, compound

Participants

Reaction Steps

10 cm3 of thionyl chloride are added at 22° C. under an argon atmosphere to 1 g (3 mmol) of 3-carboxy-5-methyl-1-(quinol-4-yl)-1H-indole. After stirring at reflux for 2.5 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa), successively triturated twice with 5 cm3 of dimethoxyethane and then concentrated to dryness under reduced pressure (2.7 kPa) to give 1 g of 3-chlorocarbonyl-5-methyl-1-(quinol-4-yl)-1H-indole hydrochloride in the form of a yellow solid which is used directly in the following step.

Provenance & Evidence