Methacrylic Acid → HCID 57679345, compound

Participants

Reaction Steps

A mixture of 31.8 g of 2-phenyl-3-o-tolyl-thiophene (0.127 mol) and 13.3 ml of methacrylic acid (0.157 mol) was added within 30 minutes at about 80° C. to 500 ml of Eaton's reagent. On completion of the addition, the reaction mixture was stirred for a further 5 minutes and then gradually added to crushed ice. 300 ml of dichloromethane were added to dissolve the reaction product. The organic phase was removed, washed with a saturated aqueous solution of sodium hydrogencarbonate and dried over magnesium sulfate. After removing the solvent, 39 g of product (3) were obtained which, according to GC-MS, constituted a single, isomer and had a purity of 95%.

Provenance & Evidence