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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 492233Generated: October 29, 2026

Phthalic Anhydride → 2-benzyl-3-hydroxy-2,3-dihydro-1H-isoindol-1-one

https://huagongshe.com/reaction/492233

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhthalic AnhydrideHCID 6811—
ReactantBenzylamineHCID 7504—
ReactantHCID 4616003HCID 4616003—
Product2-benzyl-3-hydroxy-2,3-dihydro-1H-isoindol-1-oneHCID 3240743—

Reaction Steps

Compound 20 was prepared using the synthetic sequence in a manner analogous to the method described for the conversion of commercially available phthalic anhydride 1 to compound 12 using benzylamine instead of thiophene-2-methylamine in the first step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07531671B2
Source datasetuspto-grants-2009_05
ORD IDord-1b08696a1732412b88a7d0b38cf42d2c
Source noteuspto-grants-2009_05