HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzyl alcohol → HCID 69055850, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzyl alcohol | HCID 69331 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Hydroxyindole-2-carboxylic acid | HCID 88958 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 69055850 | HCID 69055850 | — |
Reaction Steps
Diisopropylethylamine (673 μL) was added to a DMF solution (2.0 mL) of 5-hydroxyindole-2-carboxylic acid (516 mg), 4-amino-benzyl alcohol (262 mg) and HATU (734 mg), and stirred at room temperature for 2.5 hours. The reaction liquid was diluted with ethyl acetate, and the organic layer was washed with aqueous saturated sodium hydrogencarbonate solution and saturated saline water. The organic layer was dried with anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was diluted with diethyl ether and the resulting crystal was taken out through filtration to obtain 5-(benzyloxy)-N-[4-(hydroxymethyl)phenyl]-1H-indole-2-carboxamide (541 mg) as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07531668B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-91bbd5eca8cf4404bea7c50ea0c9892f |
| Source note | uspto-grants-2009_05 |