Bromine → 2-Bromo-1-(4-cyclohexylphenyl)ethanone

HRID 492268Notes

Reaction equation

HRID 492268 reaction equation
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH2:14][C:13]([C:10]1[CH:9]=[CH:8][C:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)=[CH:12][CH:11]=1)=[O:15]

Participants

4

Reactant 2

HCID 24408BromineHCID 877151-(4-Cyclohexylphenyl)ethan-1-one

Product 1

HCID 27568992-Bromo-1-(4-cyclohexylphenyl)ethanone

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
0 °C

Procedure

50 Parts of 4′-cyclohexylacetophenone was dissolved in 250 parts of chloroform, After cooled to 0° C., 40 parts of bromine was added dropwise thereto. After the reaction, the mixture was washed with 5% aqueous NaHSO3 solution, with 2% aqueous K2CO3 solution and with water, organic layer obtained was concentrated to obtain 60 parts of 2-bromo-4′-cyclohexylacetophenone.

Workup

  1. customAfter the reaction
  2. washthe mixture was washed with 5% aqueous NaHSO3 solution, with 2% aqueous K2CO3 solution and with water, organic layer
  3. customobtained
  4. concentrationwas concentrated

Sources & evidence

ORD record
ord-2abd4d1de82b44f190ab96a2afe2a1d2
Source dataset
uspto-grants-2009_05
Patent number
US07531686B2

Reaction notes

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