関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(4-Bromo-3-fluorophenyl)cyclopropane-1-carboxylic acid | HCID 11651804 | — |
| 反応物 | Hydroxyl phenylboronic acid acid | HCID 58822967 | — |
| 触媒 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 1-(2-Fluoro-4'-hydroxy-biphenyl-4-yl)-cyclopropanecarboxylic acid | HCID 11601491 | — |
反応手順
To a solution of K2CO3 (447 mg, 3.2 mmoles) in dioxane (30 ml) and water (3 ml), 250 mg of 1-(4-bromo-3-fluoro-phenyl)-cyclopropanecarboxylic acid (1.0 mmole) and 265 mg of hydroxyphenylboronic acid (1.9 mmoles) are added under stirring. Under nitrogen atmosphere, 39 mg of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (PdCl2-DPPF) are added. The resulting mixture is heated at 65° C. for one hour, then the reaction is quenched by adding a 10% w/v HCl solution.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07531692B2 |
|---|
| 出典データセット | uspto-grants-2009_05 |
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| ORD ID | ord-f2a4d599fe144044bbecca06e5396d45 |
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| 出典メモ | uspto-grants-2009_05 |
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