1-Heptanamine → HCID 68851373, compound

HRID 492288Notes

Reaction equation

[CH2:1]([NH2:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[C:9]1([C:15]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[N:16]2[C:20]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3C3C=CC(CBr)=CC=3)=[N:19][N:18]=[N:17]2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH:47]1([N:53]=[C:54]=[O:55])[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]1>>[CH:47]1([NH:53][C:54]([N:8]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[CH2:1][C:2]2[CH:7]=[CH:6][C:5]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[C:20]3[N:16]([C:15]([C:41]4[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=4)([C:35]4[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=4)[C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=4)[N:17]=[N:18][N:19]=3)=[CH:4][CH:3]=2)=[O:55])[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]1

Participants

Reactant 3

HCID 81271-Heptanamine

HCID 18502Cyclohexyl isocyanate

HCID 100534615-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole

Product 1

HCID 68851373HCID 68851373, compoundYield 88.7%

Procedure

Using n-heptylamine (192 mg), [[2′-[N-(triphenylmethyl)tetrazol-5-yl]-1,1′-biphenyl-4-yl]methyl] bromide (843 mg) and cyclohexyl isocyanate (230 mg), N-cyclohexyl-N′-heptyl-N′-[[2′-[N-(triphenylmethyl)tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]urea (0.53 g) was obtained in a similar manner as in Example 5. Yield: 49%.

Sources & evidence

ORD record: ord-63a96eaad8e34d6a89e5bfcc84c03e4b
Source dataset: uspto-grants-2009_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07531576B2

Reaction notes

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