Dimethylformamide → N-[[2'-[(t-butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl]-N-heptylamine

Participants

Reaction Steps

[[2′-[(t-Butylamino)sulfonyl]-1,1′-biphenyl-4-yl]methyl] bromide (0.94 g), n-heptylamine (0.28 g) and potassium carbonate (0.35 g) were added to dimethylformamide and the mixture was stirred at room temperature. Sixteen hours and 30 minutes later, ethyl acetate (30 mL) was added, and the resulting mixture was washed three times with brine (100 mL, each). The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was subjected to chromatography on a silica gel column (chloroform/ethyl acetate) to afford N-[[2′-[(t-butylamino)sulfonyl]-1,1′-biphenyl-4-yl]methyl]-N-heptylamine as a yellow oil (0.43 g). Yield: 42%.

Provenance & Evidence