Triethylamine → N'-[[2'-[(t-butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl]-N'-heptyl-N-(2,4,6-trifluorophenyl)urea

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	P,P-Diphenylphosphinic azide	HCID 199401	—
Reactant	2,4,6-Trifluorobenzoic acid	HCID 520373	—
Reactant	N-[[2'-[(t-butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl]-N-heptylamine	HCID 68851407	—
Product	N'-[[2'-[(t-butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl]-N'-heptyl-N-(2,4,6-trifluorophenyl)urea	HCID 68851965	81%

Reaction Steps

Using 2,4,6-trifluorobenzoic acid (0.27 g), diphenylphosphoryl azide (0.44 g), triethylamine (0.17 g) and N-[[2′-[(t-butylamino)sulfonyl]-1,1′-biphenyl-4-yl]methyl]-N-heptylamine (0.43 g), N′-[[2′-[(t-butylamino)sulfonyl]-1,1′-biphenyl-4-yl]methyl]-N′-heptyl-N-(2,4,6-trifluorophenyl)urea was afforded as colorless crystals (0.49 g) by a similar procedure as in Example 4. Yield: 81%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07531576B2
Source dataset	uspto-grants-2009_05
ORD ID	ord-93713c4e2de840a385d60127aa87377e
Source note	uspto-grants-2009_05