Magnesium Chloride → HCID 131722775, compound

HRID 49241Notes

Reaction equation

HRID 49241 reaction equation
[Na].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]2[N:11]=[C:10]([S:12]([CH2:14][C:15]3[C:20]([CH3:21])=[C:19]([O:22][CH3:23])[C:18]([CH3:24])=[CH:17][N:16]=3)=[O:13])[NH:9][C:8]=2[CH:25]=1.[Cl-].[Mg+2:27].[Cl-]>O>[OH2:3].[OH2:3].[OH2:3].[OH2:3].[Mg:27].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]2[N:11]=[C:10]([S@:12]([CH2:14][C:15]3[C:20]([CH3:21])=[C:19]([O:22][CH3:23])[C:18]([CH3:24])=[CH:17][N:16]=3)=[O:13])[NH:9][C:8]=2[CH:25]=1

Participants

4

Reactant 2

HCID 5360315Magnesium Chloride2×HCID 9842204(R)-Omeprazole Sodium Salt

Product 1

HCID 131722775HCID 131722775, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

1.65 g of 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt was dissolved in 30 mL of water. To the stirring solution was added 0.47 g of magnesium chloride dissolved in 20 mL of water. Immediately upon the addition of the magnesium chloride solution a white powder precipitated. The suspension was allowed to stir for 5 minutes, and then the product was isolated by vacuum filtration. The solids were then, placed into a vacuum desiccator overnight to give the desired product as a white powder. A small portion of the powder was dissolved in methanol at about 75 mg/mL, filtered and diluted with a equal volume of water. This solution was partially covered and set aside to slowly evaporate. After approximately 5 days, crystals were isolated, analyzed by single-crystal x-ray diffraction and shown to be the desired product.

Workup

  1. customprecipitated
  2. customthe product was isolated by vacuum filtration
  3. customplaced into a vacuum desiccator overnight

Sources & evidence

ORD record
ord-c6816974408a42fc9b96a484a81668c8
Source dataset
uspto-grants-2004_03
Patent number
US06706737B2

Reaction notes

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