Hydrogen Peroxide → 3-Bromo-4-(5-formyl-pyridin-2-yloxy)-benzamide

Participants

Role	Name	HCID	Charge
Reactant	Hydrogen Peroxide	HCID 784	—
Reactant	Water	HCID 962	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	3-Bromo-4-(5-formyl-pyridin-2-yloxy)-benzonitrile	HCID 59729966	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Product	3-Bromo-4-(5-formyl-pyridin-2-yloxy)-benzamide	HCID 59730277	100.5%

Reaction Conditions

Temperature	0 °C

Reaction Steps

Combine 3-bromo-4-(5-formyl-pyridin-2-yloxy)-benzonitrile (1.60 g, 5.28 mmol) and potassium carbonate (365 mg, 2.64 mmol) in DMSO (40 mL). Cool the reaction mixture at 0° C. Add hydrogen peroxide (1.59 mL, 5.28 mmol) dropwise and let the reaction stir at room temperature for 2 h. Pour into water and triturate to a white solid with stirring. Filter the white solid and dry to give (852 mg, 82%) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07531557B2
Source dataset	uspto-grants-2009_05
ORD ID	ord-9dcfbcc69edf40bc8e52ca4c2fdf7384
Source note	uspto-grants-2009_05