Dimethylformamide → HCID 44434063, compound

Participants

Reaction Steps

Combine 6-(1,2,3,4-tetrahydro-isoquinolin-6-yloxy)-nicotinamide (46.9 mg, 0.17 mmol), DMF (3 mL). Et3N (0.1 mL, 0.77 mmol), and phenethylbromide (52 uL, 0.38 mmol) in a 7 mL vial. Place the reaction vial on a shaker at 70° C. for 72 hours, and then add water and ethyl acetate. Wash the ethyl acetate layer several times with water, 10% LiCl, and dry over Na2SO4. Concentrate organic mixture and flash chromatograph using 30% THF, 4% 1.0 N NH3 in MeOH, 76% CH2Cl2 to afford 23.2 mg, (37% yield) of the title compound: MS m/z 374 (M+1).

Provenance & Evidence