HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 6-(2-Fluoro-4-formyl-6-methoxy-phenoxy)-nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde | HCID 598452 | — |
| Reactant | 6-Chloro-3-pyridinecarbonitrile | HCID 5152094 | — |
| Product | 6-(2-Fluoro-4-formyl-6-methoxy-phenoxy)-nicotinonitrile | HCID 85957486 | 66.9% |
Reaction Steps
Using a method similar to Example 710, Step 2, using 3-fluoro-4-hydroxy-5-methoxy-benzaldehyde (Journal of Organic Chemistry (1986), 51(2H), 4072-3.) (2.84 g, 16.7 mmol), 6-chloronicotinonitrile (2.31 g, 16.7 mmol) and K2CO3 (3.46 g, 25.0 mmol) gives 6-(2-fluoro-4-formyl-6-methoxy-phenoxy)-nicotinonitrile (3.04 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07531557B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-63c9406a6ded418ca7621ce9f8cfa367 |
| Source note | uspto-grants-2009_05 |