HCID 86759037, compound → HCID 86759036, compound

Participants

Reaction Conditions

Reaction Steps

To E7 (184 mg) dissolved in tert-butanol at 40° C. was added Pd/C (50 mg) and the atmosphere changed to hydrogen. The hydrogenation was heated at 40° C. for 3 days, the catalyst filtered off and the solvent removed. The residues were purified by silica chromatography eluting initially with 100:10:0 CH2Cl2:MeOH:NH4OH to remove faster running impurities then with 100:10:1 to remove the title compound as a colourless gum, 61 mg, 34%. C91H178N8O13 requires 1591.3. Found ES+: MH+, 1592.3. δH (CDCl3) 1.24 (72H, br, H2N(CH2)2(CH2)32, CONH(CH2)2(CH2)4), 1.44 (66H, br, (Me)3C, CH2CH2N), 1.72 (4H, p, NCH2CH2CH2N), 1.98 (1H, br, CH), 2.14 (2H, t, CH2CO), 2.67 (2H, t, CH2NH2), 2.83 (6H, s, NMe), 2.95-3.30 (22H, m, NCH2), 5.62 (1H, br, CONH(CH2)6CH).

Provenance & Evidence