Ammonium Chloride → HCID 23153283, compound

Participants

Reaction Steps

2-[(Dimethylamino)carbonylamino]-4-(2-fluoro-4-nitrophenoxy)pyridine (218 mg) was dissolved in ethanol (20 ml)-water (5 ml) to dissolve, and then electrolytic iron powder (250 mg) and ammonium chloride (500 mg) were added thereto, followed by heating under reflux for 1 hr. The reaction mixture was cooled down to room temperature, and then ethyl acetate-tetrahydrofuran (1:1) was added thereto, followed by stirring. An insoluble portion was filtered through celite, and washed with ethyl acetate and water. The organic layer of the filtrate was separated, washed with water and brine in this order, and dried over anhydrous sodium sulfate. The solvent was evaporated under a reduced pressure to give a residue, to which thus diethyl ether-hexane was then added to suspend. Crystals was filtered off and dried under aeration to provide the titled compound (180 mg, 91%) as pale yellow crystals.

Provenance & Evidence