反应详情

To a solution of 4-(4-nitro-3-trifluoromethylphenoxy)pyridin-2-ylamin (400 mg, 1.34 mmol) in methanol (20 ml) was added 10% palladium carbon (146 mg), followed by stirring under a hydrogen atmosphere at room temperature for 10 hrs. The reaction mixture was filtered to remove the catalyst. The filtrate was concentrated under a reduced pressure to give a residue, which was then purified by silica gel column chromatography (eluent; ethyl acetate) to provide the titled compound (201 mg, 55.4%) as a brown oil.

1. filtrationThe reaction mixture was filtered
2. customto remove the catalyst
3. concentrationThe filtrate was concentrated under a reduced pressure
4. customto give a residue, which
5. customwas then purified by silica gel column chromatography (eluent; ethyl acetate)