HCID 23153349, compound → HCID 23153214, compound

Participants

Reaction Steps

4-{[4-(Dimethylaminomethyl)piperidin-1-yl]carbonylamino}-6-(2-fluoro-4-nitrophenoxy)pyrimidine (136 mg) was dissolved in tetrahydrofuran (15 ml). After adding 20% palladium hydroxide-carbon (100 mg), the mixture was stirred overnight under a hydrogen atmosphere. The catalyst was filtered and washed with tetrahydrofuran. The filtrate and the washings were combined and concentrated under reduced pressure, and the resultant residue was dried under reduced pressure to provide the title compound (118 mg, 94%) as a colorless oil.

Provenance & Evidence