4-Isopropylphenol → HCID 22925854, compound

Participants

Reaction Steps

To 50 ml of dehydrated ethyl acetate (AcOEt) were added 5.0 g (36.7 mmol) of 4-isopropylphenol and 1.7 ml of hydrochloric acid/ether (HCl-Ether) solution (1.0 mol/L), and temperature of the reaction system was controlled to 40° C. Ethyl vinyl ether (7.9 g: 109.6 mmol) was added dropwise to the mixture, and the resultant mixture was stirred overnight. After the completion of the reaction, the reaction mixture was washed with an aqueous solution of sodium hydrogencarbonate, and washed with water to remove the solvent. Thus obtained mixture was purified by silica gel column chromatography (eluent: hexane) to provide 7.0 g (33.6 mmol) of 1-(1-ethoxy)ethoxy-4-isopropylbenzene.

Provenance & Evidence