4-(4-propoxyphenyl)benzoic Acid → HCID 22925874, compound

HRID 493045Notes

Reaction equation

HRID 493045 reaction equation
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)[CH2:2][CH3:3]>S(Cl)(Cl)=O>[CH2:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:19]=[CH:18][C:14]([C:15]([O:17][C:8]([CH3:11])([CH3:9])[CH3:7])=[O:16])=[CH:13][CH:12]=2)=[CH:9][CH:10]=1)[CH2:2][CH3:3]

Participants

3

Reactant 1

HCID 20636134-(4-propoxyphenyl)benzoic Acid

Product 1

HCID 22925874HCID 22925874, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

Thionyl chloride (10 ml) was added to 5.0 g (19.5 mmol) of 4-(4-n-propyloxyphenyl)benzoic acid synthesized in the step (ii), and the mixture was refluxed overnight. After an excess amount of thionyl chloride was removed from the resultant mixture, 4′-(n-propyloxy)-4-(tert-butoxycarbonyl)biphenyl was obtained in the same manner as in the Example 104.

Workup

  1. customsynthesized in the step (ii)
  2. temperaturethe mixture was refluxed overnight
  3. customAfter an excess amount of thionyl chloride was removed from the resultant mixture

Sources & evidence

ORD record
ord-53786bc9e3f642faa0c790f2397e53ac
Source dataset
uspto-grants-2009_05
Patent number
US07534547B2

Reaction notes

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