反应详情

To a solution of the epoxide 6 (2.5 g, 9 mmol) in anhydrous ether (75 mL) at 0° C. was added lithium aluminum hydride (1.7 g, 67.5 mmol). The cooling bath was removed and the reaction was stirred at room temperature overnight. The reaction was then quenched with cold water and aqueous NH4Cl, and extracted with CH2Cl2. The solvents were removed under reduced pressure and the crude oil was chromatographed on a silica gel using hexane/EtOAc (9:1) as an eluent to give an oily alcohol 7 (2 g, 80%).

1. customThe cooling bath was removed
2. customThe reaction was then quenched with cold water and aqueous NH4Cl
3. extractionextracted with CH2Cl2
4. customThe solvents were removed under reduced pressure
5. customthe crude oil was chromatographed on a silica gel