6-Methyltetralin → HCID 55279233, compound

HRID 493077Notes

Reaction equation

HRID 493077 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[CH:3]=1.[Cl:12][S:13](O)(=[O:15])=[O:14]>C(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[C:3]=1[S:13]([Cl:12])(=[O:15])=[O:14]

Participants

4

Reactant 2

HCID 155146-MethyltetralinHCID 24638Chlorosulfonic acid

Product 1

HCID 55279233HCID 55279233, compoundYield 95.4%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 20 g (0.137 mol) 2-methyl-5,6,7,8-tetrahydro-naphthalene in 200 mL CHCl3 was added to 48 g (0.412 mol) chlorosulfonic acid at 0° C. After 2 hrs at room temperature the solution was slowly poured onto ice. The organic phase was washed, dried and concentrated to give 32 g 2-methyl-5,6,7,8-tetrahydro-naphthalene-sulfonic acid chloride used directly for the subsequent reaction.

Workup

  1. additionAfter 2 hrs at room temperature the solution was slowly poured onto ice
  2. washThe organic phase was washed
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-3b70eee85eef430f975218eb6ca5f9fa
Source dataset
uspto-grants-2009_05
Patent number
US07534787B2

Reaction notes

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