Methanesulfonic Acid → HCID 20634953, compound

Participants

Reaction Steps

To a solution of 1,4-bis[5-(3,5-dimethoxy-4-methylphenyl)-2-pyridyl]hexahydro-1,4-diazepine (77.0 mg, 0.140 mmol) in methanol (5.0 mL) was added a 1.0 M aqueous methanesulfonic acid (0.28 mL, 0.28 mmol), and the reaction mixture was concentrated under reduced pressure. Ethanol (5.0 mL) was added to the residue, and the resulting mixture was concentrated under reduced pressure. The residue was recrystallized from methanol-chloroform-diethyl ether to yield the title compound as a pale yellow crystalline powder (melting point: 235.0-237.0° C. (67.0 mg, yield: 64%).

Provenance & Evidence