Water → HCID 68900017, compound

Participants

Reaction Steps

LiOH (480 mg, 20 mmol) is added to 2-(benzo[b]thiophen-3-ylsulfanyl)-5-methyl-benzoic acid methyl ester (630 mg, 2 mmol) in 16 mL mixture of THF/water (3:1). The reaction mixture is refluxed for 2 hours and cooled to room temperature. Water and ethyl acetate is added and the organic phase is washed with brine, dried with MgSO4 and concentrated in vacuo to give the title compound, which is used in the next step without further purification.

Provenance & Evidence