HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxa-8-azaspiro(4.5)decane → HCID 68982573, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | HCID 67435 | — |
| Reactant | Ytterbium triflate | HCID 2733225 | — |
| Reactant | HCID 11275682 | HCID 11275682 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68982573 | HCID 68982573 | — |
Reaction Steps
[R]-2-(6-Methoxyquinolin-4-yl)oxirane (1b) (470 mg) and 1,4-dioxa-8-azaspiro-[4,5]-decane (0.33 ml) were dissolved in dry dichloromethane (5 ml) and ytterbium triflate (30 mol %) was added. The mixture was stirred for 6 hours, filtered through celite, evaporated and chromatographed on silica gel (dichloromethane then methanol-dichloromethane) to afford the title compound (690 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07534793B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-0443a2d7c1c14a0d89a24d48f0a7e270 |
| Source note | uspto-grants-2009_05 |