1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, methyl ester → 1H-Pyrrolo[3,2-b]pyridine-2-carbaldehyde

HRID 493120Notes

Reaction equation

HRID 493120 reaction equation
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10](OC)=[O:11]>[O-2].[Mn+2]>[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH:10]=[O:11]

Participants

3

Reactant 1

HCID 222817761H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, methyl ester

Product 1

HCID 222817391H-Pyrrolo[3,2-b]pyridine-2-carbaldehyde

Reagents, catalysts & solvents 1

HCID 160959Manganese oxideCatalyst

Procedure

This was prepared from methyl 1H-pyrrolo[3,2-b]pyridin-2-carboxylate (0.1 g) and amine (1d) by the method of Example 16c, (except that the alcohol was stirred with manganese (II) oxide overnight) and used without purification.

Workup

  1. customused without purification

Sources & evidence

ORD record
ord-2013d80509a948508dd67b5e79197f46
Source dataset
uspto-grants-2009_05
Patent number
US07534793B2

Reaction notes

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