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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 493123Generated: October 31, 2026

Ethyl Acetate → ethyl 4,7-difluoro-1H-indole-2-carboxylate

https://huagongshe.com/reaction/493123

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl AcetateHCID 8857—
ReactantHCID 22281717HCID 22281717—
Productethyl 4,7-difluoro-1H-indole-2-carboxylateHCID 22281774—

Reaction Steps

The cooled mixture was dissolved in ethyl acetate, washed with sodium bicarbonate and brine, dried and evaporated. Chromatography on silica gel (1:1 dichloromethane/petrol) followed by recrystallization (dichloromethane/hexane) gave the indole ester (0.75 g). (f) 4,7-Difluoroindole-2-carboxaldehyde

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07534793B2
Source datasetuspto-grants-2009_05
ORD IDord-dd3df5976fb640cbaad59042b33b9d69
Source noteuspto-grants-2009_05