反应详情

温度

60 °C

A mixture of 3-(4-nitrophenoxy)propanoic acid (6.5 g, 30 mmol), concentrated sulfuric acid (30 mL) and phosphorus pentoxide (5.2 g, 37 mmol) is stirred at 60° C. for 3 hours, poured onto ice, stirred for 15 minutes and extracted with ethyl acetate. The organic phase is washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a beige solid, 5.5 g (94% yield) mp 171-173° C., identified by NMR and mass spectral analyses.

1. additionpoured onto ice
2. stirringstirred for 15 minutes
3. extractionextracted with ethyl acetate
4. washThe organic phase is washed with saturated aqueous sodium bicarbonate
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated in vacuo