Hydrochloric Acid → HCID 69092455, compound

Participants

Reaction Steps

A mixture of benzyl 4-{6-[(phenylsulfonyl)amino]-2,3-dihydro-4H-chromen-4-ylidene}piperidine-1-carboxylate (500 mg, 1 mmol), ethanol (2 mL) and 6N hydrochloric acid (18 mL) is heated at reflux temperature for 2 hours, cooled to 0°-5° C., treated with 6N sodium hydroxide (14 mL) with cooling, then with saturated aqueous sodium carbonate to pH 9 and with chloroform. The organic phase is dried over MgSO4 and concentrated in vacuo. The resultant residue is crystallized from ethanol to afford the title compound as an off-white solid, 75 mg (20% yield), mp >230° C., identified by NMR and mass spectral analyses.

Provenance & Evidence