3-Amino-4-hydroxybenzoic acid → 2-(2-(4-Pentylphenylsulfonamido)ethyl)benzo[d]oxazole-5-carboxylic acid

HRID 493155Notes

Reaction equation

HRID 493155 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][NH:12][S:13]([C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:18][CH:17]=1)(=[O:15])=[O:14].NC1C=C(C=CC=1O)[C:31]([OH:33])=[O:32]>>[CH2:22]([C:19]1[CH:18]=[CH:17][C:16]([S:13]([NH:12][CH2:11][CH2:10][C:2]2[O:1][C:5]3[CH:6]=[CH:7][C:8]([C:31]([OH:33])=[O:32])=[CH:9][C:4]=3[N:3]=2)(=[O:14])=[O:15])=[CH:21][CH:20]=1)[CH2:23][CH2:24][CH2:25][CH3:26]

Participants

3

Reactant 2

HCID 650833-Amino-4-hydroxybenzoic acidHCID 15953816N-[2-(1,3-Benzoxazol-2-yl)ethyl]-4-pentylbenzene-1-sulfonamide

Product 1

HCID 690643992-(2-(4-Pentylphenylsulfonamido)ethyl)benzo[d]oxazole-5-carboxylic acid

Procedure

The title compound of Step 1 was prepared following the procedure described above for the preparation of the product of Step 3 of Example 1, substituting 3-amino-4-hydroxybenzoic acid in place of o-aminophenol. MS m/e 417; HPLC retention time 3.50 min.

Sources & evidence

ORD record
ord-804f038299214bf897815c8ea13f85f3
Source dataset
uspto-grants-2009_05
Patent number
US07534804B2

Reaction notes

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