反应详情

To a solution of 2-hydroxy-5-methoxybenzaldehyde (21.75 g, 143 mmol) in 240 mL acetonitrile were successively added Cs2CO3 (55.9 g, 1.2 eq.) and ethyl bromoacetate (16.6 mL, 1.05 eq.) and the mixture vigorously stirred at ambient temperature for 2 h. Pouring onto crashed ice/NH4Cl, twofold extraction with AcOEt, washing with water and brine, drying over magnesium sulfate, and evaporation of the solvents left 34.36 g of the title product, sufficiently pure to be used for the next step.

1. additionPouring
2. extractionice/NH4Cl, twofold extraction with AcOEt
3. washwashing with water and brine
4. dry with materialdrying over magnesium sulfate, and evaporation of the solvents
5. waitleft 34.36 g of the title product