関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Boron tribromide | HCID 25134 | — |
| 反応物 | 2-Benzofurancarboxylic acid, 5-methoxy-, ethyl ester | HCID 521283 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Ethyl 5-hydroxybenzofuran-2-carboxylate | HCID 22228632 | — |
反応手順
The above prepared 5-methoxy-benzofuran-2-carboxylic acid ethyl ester (8.10 g, 36.8 mmol) was dissolved in 250 mL of CH2Cl2, cooled to 0° C., and treated with BBr3 (73.6 mL of 1M solution in CH2Cl2, 2 eq.). After 2 h, the reaction mixture was carefully poured onto crashed ice, twofold extracted with CH2Cl2, washed with brine, dried over magnesium sulfate, and evaporated to dryness. Ensuing flash chromatography (SiO2, hexane/AcOEt=8/2) delivered then 5.63 g of the title compound as off-white crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07534788B2 |
|---|
| 出典データセット | uspto-grants-2009_05 |
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| ORD ID | ord-fae4dd29020d4c56ba37b03c148f2d48 |
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| 出典メモ | uspto-grants-2009_05 |
|---|
