反应详情

温度

0 °C

The above prepared ((cis)-2,6-dimethyl-morpholin-4-yl)-(5-methoxy-benzofuran-2-yl)-methanone (0.614 g, 2.12 mmol) was dissolved in 14 mL of CH2Cl2, cooled to 0° C., and treated with BBr3 (4.24 mL of 1M solution in CH2Cl2, 2 eq.). After 1 additional h at RT, the reaction mixture was carefully poured onto crashed ice, twofold extracted with AcOEt, washed with water, dried over sodium sulfate, and evaporated to dryness. Ensuing flash chromatography (SiO2, hexane/AcOEt=1/1) yielded 0.556 g of the title compound as off-white solid.

1. additionAfter 1 additional h at RT, the reaction mixture was carefully poured
2. extractiontwofold extracted with AcOEt
3. washwashed with water
4. dry with materialdried over sodium sulfate
5. customevaporated to dryness