1-Isopropylpiperazine → HCID 68880149, compound

Participants

Reaction Steps

In a flask were mixed together the above prepared 5-(1-isopropyl-piperidin-4-yloxy)-benzofuran-2-carboxylic acid (0.220 g, 0.549 mmol, corrected for purity), 1-isopropylpiperazine (0.084 g, 1.2 eq.), (benzotriazol-1-yloxy)-tris-(dimethylamino)-phosphonium hexafluorophosphate (0.291 g, 1.2 eq.) and 2.4 eq. of N-ethyldiisopropyl-amine (0.225 mL) in 2.2 mL of abs. THF and allowed to react during one night at ambient temperature. Pouring onto crashed ice/AcOEt/NH4Cl-solution, twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents, followed by flash chromatography (SiO2, NEt3/AcOEt=4/96) produced 0.127 g of the title compound as light yellow oil.

Provenance & Evidence