Hydrochloric Acid → 5-(1-Isopropyl-piperidin-4-yloxy)-benzo[b]thiophene-2-carboxylic acid

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Reaction Steps

The above prepared 5-(1-isopropyl-piperidin-4-yloxy)-benzo[b]thiophene-2-carboxylic acid methyl ester (0.222 g, 0.666 mmol) was dissolved in 1.3 mL of THF/ethanol=1/1 and treated with 0.333 mL of aq. NaOH (3M, 1.5 eq.). The mixture was stirred for 2 h at ambient temperature and was then neutralized by adding 0.50 mL of 2M HCl (1.5 eq.). Careful evaporation of all solvents, trituration in diethyl ether, and drying afforded then 0.256 g of the title compound as white solid, contaminated with innocouos inorganic salts.

Provenance & Evidence