Hydrochloric Acid → HCID 68724457, compound

Participants

Reaction Steps

The above prepared 3-isopropyl-6-(1-isopropyl-piperidin-4-yloxy)-benzofuran-2-carboxylic acid ethyl ester (0.720 g, 1.54 mmol, corrected for purity) was dissolved in 4 mL of THF/ethanol=1/1 and treated with 0.771 mL of aq. NaOH (3M, 1.5 eq.). The mixture was stirred for 3 h at ambient temperature and was then neutralized by adding 1.16 mL of 2M HCl (1.5 eq.). Careful evaporation of all solvents and drying afforded then 0.800 g of the title compound as light yellow foam contaminated with innocouos inorganic salts.

Provenance & Evidence