1,3-Dimethoxybenzene → (2,4-Dimethoxyphenyl)(4-fluorophenyl)methanone

Participants

Reaction Conditions

Reaction Steps

1,3-Dimethoxybenzene (5.00 g, 36.2 mmol) and AlCl3 (5.79 g, 1.2 eq.) were dissolved in 360 ml of CH2Cl2 and cooled down to 0° C. 4-Fluoro-benzoyl chloride (4.34 mL, 1.0 eq.) was slowly added via dropping funnel and the mixture allowed to react for another h at ambient temperature. Pouring onto crashed ice, twofold extraction with AcOEt, washing with water and brine, drying over sodium sulfate, and evaporation of the solvents, followed by short flash chromatography (SiO2, hexane/AcOEt 8/2), yielded 7.75 g of the title compound as white solid.

Provenance & Evidence