HCID 68725817, compound → HCID 68726944, compound

Participants

Reaction Steps

The above prepared [4-chloro-2-(hydroxy-phenyl-methyl)-5-methoxy-phenoxy]-acetic acid ethyl ester (1.91 g, 3.81 mmol, corrected for purity) was dissolved in 50 mL of CH2Cl2, treated with MnO2 (8.28 g, 25 eq.), and the reaction mixture vigorously stirred over night. Filtration over a pad of Celite, carefully rinsing, and evaporation of the solvent, followed by flash chromatography (SiO2, heptane/AcOEt=7/3) and crystallization from heptane/AcOEt gave 0.530 g of the title compound as white crystals.

Provenance & Evidence