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温度

0 °C

Chloro-2,4-Dimethoxy-benzene (5.00 g, 29.0 mmol) and AlCl3 (4.63 g, 1.2 eq.) were dissolved in 290 ml of CH2Cl2 and cooled down to 0° C. 4-Fluoro-benzoyl chloride (3.47 mL, 1.0 eq.) was slowly added via dropping funnel and the mixture allowed to react for 2 additional h at ambient temperature. Pouring onto crashed ice, twofold extraction with AcOEt, washing with brine, drying over sodium sulfate, and evaporation of the solvents left 8.41 g of the title compound used crude for the next step.

1. customto react for 2 additional h at ambient temperature
2. additionPouring
3. extractionice, twofold extraction with AcOEt
4. washwashing with brine
5. dry with materialdrying over sodium sulfate, and evaporation of the solvents
6. waitleft 8.41 g of the title compound used crude for the next step