反应详情

To a solution of the above prepared 1-(5-chloro-2-hydroxy-4-methoxy-phenyl)-ethanone (4.22 g, 21.0 mmol) in 50 mL of acetonitrile were successively added Cs2CO3 (8.22 g, 1.2 eq.) and ethyl bromoacetate (2.44 mL, 1.05 eq.) and the mixture vigorously stirred at ambient temperature for 2 h. Pouring onto crashed ice/NH4Cl, twofold extraction with AcOEt, washing with water, drying over magnesium sulfate, and evaporation of the solvents left 6.05 g of the title compound as off-white solid, used directly for the next step.

1. additionPouring
2. extractionice/NH4Cl, twofold extraction with AcOEt
3. washwashing with water
4. dry with materialdrying over magnesium sulfate, and evaporation of the solvents
5. waitleft 6.05 g of the title compound as off-white solid