HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(5-Chloro-2-ethoxycarbonyl-3-methyl-benzofuran-6-yloxy)-piperidine-1-carboxylic acid tert-butyl ester | HCID 68878771 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 5-Chloro-3-methyl-6-(piperidin-4-yloxy)-benzofuran-2-carboxylic acid ethyl ester | HCID 68726453 | — |
Reaction Steps
The above prepared 4-(5-chloro-2-ethoxycarbonyl-3-methyl-benzofuran-6-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (1.457 g, 3.327 mmol) was dissolved in 8 mL of dioxane and treated with HCl (16.5 mL of 4N [dioxane], 20 eq.) and the mixture kept at ambient temperature for 2 h. Careful evaporation of all solvents and drying yielded 1.36 of the title product as hydrochloride as white crystals, which was further processed without additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07534788B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-680243f4c6494a92a2c79707874d0017 |
| Source note | uspto-grants-2009_05 |