3-Aminopyrrolidine → HCID 22036500, compound

HRID 493264Notes

Reaction equation

HRID 493264 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[N:6][CH:5]=[CH:4][N:3]=1.[NH2:19][CH:20]1[CH2:24][CH2:23][NH:22][CH2:21]1>>[NH2:19][CH:20]1[CH2:24][CH2:23][N:22]([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:21]1

Participants

3

Reactant 2

HCID 1644013-AminopyrrolidineHCID 22036540HCID 22036540, compound

Product 1

HCID 22036500HCID 22036500, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(4-chlorophenoxy)ethoxy]pyrazine* (150 mg, 0 53 mmol) and 3-aminopyrrolidine (247 mg. 2.87 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 123 mg (69%) of the title product. Anal. (C16H19Cl N4O2) H, N; C: calcd, 57.40; founds 56.9.

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-74044614c8af42c38bdcb4eb64395958
Source dataset
uspto-grants-2009_05
Patent number
US07534794B2

Reaction notes

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